NAD+ (500mg)

NAD+ is the molecule your body uses to power energy production, repair DNA damage, and activate the proteins that regulate how well your cells age. It's present in every cell and essential for almost every major biological process — but levels drop by up to 50% between your 40s and 60s. That decline is now considered by leading researchers to be one of the central mechanisms of ageing itself, not just a byproduct of it. Replenishing NAD+ is one of the most researched areas in longevity science right now.

NAD+ stands for Nicotinamide Adenine Dinucleotide — you'll sometimes see it written as just NAD without the plus sign. You may also have heard of NMN (Nicotinamide Mononucleotide) or NR (Nicotinamide Riboside) — these are precursors that the body converts into NAD+. What we supply is NAD+ itself, not a precursor.

As we get older, the body produces less NAD+ and consumes it faster — particularly because DNA damage accumulates with age, and the repair enzymes (PARPs) that fix it burn through NAD+ rapidly. At the same time, an enzyme called CD38 becomes more active with age and degrades NAD+. The result is a progressively lower pool that leaves cells less able to produce energy, repair themselves, and maintain healthy function. This is why researchers focus on NAD+ replenishment as a core longevity strategy.

Research in both animal models and early human trials points to improvements in energy levels, metabolic efficiency, cognitive clarity, and physical recovery. In animal models, restoring NAD+ has reversed measurable aspects of muscular and metabolic ageing. For human subjects, early trials have documented improvements in muscle function, insulin sensitivity, and cellular energy markers. Individual results in research settings vary, but the consistent theme across the literature is that higher NAD+ correlates with better cellular performance across multiple systems.

The research base for NAD+ is substantial and growing fast. Studies have directly linked declining NAD+ to mitochondrial dysfunction, impaired DNA repair, chronic inflammation, and metabolic decline. Animal studies have shown that restoring NAD+ can reverse some of these changes — improving muscle function, cognitive performance, and metabolic health markers. David Sinclair's lab at Harvard, among others, has published extensively on NAD+ as a central regulator of the ageing process. Human clinical trials are ongoing, with early data supporting measurable improvements in energy metabolism and cellular health.

NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) are precursors — the body has to convert them into NAD+ before they can be used. NAD+ is the active molecule itself. Whether direct NAD+ or a precursor is more effective for a given research application is an active area of study, with different researchers using different approaches depending on protocol design and administration route.

NAD+ is supplied as a lyophilized powder and should be reconstituted with bacteriostatic water (BAC water) immediately before use. Inject the BAC water slowly into the vial, directing the stream down the inside wall. Gently swirl to dissolve — do not shake. Once reconstituted, store at 2–8°C and use within 28 days. For a full step-by-step walkthrough, see our complete peptide reconstitution guide.

Store lyophilized NAD+ vials at -20°C, away from light and moisture. After reconstitution, refrigerate at 2–8°C and use within 28 days. Do not freeze the reconstituted solution.

NAD+ (500mg) is available through Aussie Peptides with fast domestic shipping to all Australian states and territories. Every vial is dispatched from within Australia — no customs delays, no international freight uncertainty. Each batch undergoes third-party analysis and the Certificate of Analysis is available to view in our CoA library.

NAD+ (500mg) is priced at $129.99 per vial at Aussie Peptides. All orders ship domestically within Australia, and batch CoAs are available in our CoA library.